LAG-3 Immune Checkpoint Molecule
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The LAG-3 receptor is an emerging targetable inhibitory immunological checkpoint protein that is expressed on murine plasmacytoid dendritic cells (DCs), activated human CD4+ and CD8+ T cells, and a subset of T cells and natural killer (NK) cells. Major Histocompatibility Complex Class II (MHC-II) molecules, which are expressed on the surface of antigen-presenting cells (APCs) and tumor cells, are the primary ligand that LAG-3 interacts with. Some possible ligands for LAG-3 are as follows:
LSETin, or liver sinusoidal endothelial cell lectin, is a DC-SIGN family member.
CD8+ T cells and stromal cells both express the protein galectin-3.
Neurons contain α-synuclein.
Fibrinogen-like protein 1, secreted by tumor cells and at low concentrations in the liver.
