Unlocking Biotechnological Potential: The Yeast Expression Platform

Yeasts provide attractive expression platforms. They combine ease of genetic manipulations and the option for a simple fermentation design of a microbial organism with the capabilities of an eukaryotic organism to secrete and to modify a protein according to a general eukaryotic scheme. A range of yeast species has been developed for various applications. Commonly used strains are Pichia pastoris, Saccharomyces cerevisiae, and occasionally Hensenula polymorpha. Creative Biogene is at the forefront of protein expression with years of experiences. Equipped with a team of professional scientists, we are capable providing our clients with a variety of customized services from concept to product to meet all your needs.

The general wokflow of a protein production includes gene expression, posttranslational modifications, protein secretion and downstream processing, each of steps requiring detailed design. Our yeast expression platform comprises an extensive collection of plasmids and host strains. We can provide excellent construct design strategies to obtain high-quality recombinant proteins. Various yeast expression systems and diversified flexible strategies can meet your sundry requirements for protein production.

The methylotrophic yeast Pichia pastoris is recognized as an excellent expression system for heterologous protein production, especially when it comes to the production of complex proteins which require typical eukaryotic post-translational modifications or contain disulfide bridges.